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    Abstract Isomerization during grinding of solid state α monohydrate α anhydrate and β anhydrate of lactose was investigated Samples were ground in an agate centrifugal ball mill at 270 rev min −1 at room temperature 20 176C The crystallinity of ground lactose was measured by Hermans method from the powder X ray diffraction profiles

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    Ball milling of lactose powders was performed in a planetary ball mill PM 100 CM Retsch Germany The milling operation was carried out in a stainless steel milling jar with a constant volume of 12 cm 3 and a diameter of 3 cm using balls of the same material of 1 5 and 10 mm in diameter The rotation speed of the solar disk revolution